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Rondinone CM, Valdecantos P, Rada P, Valverde AM, Ghosh S (2024) Novel unimolecular tetra-agonist peptides targeting GLP-1, GIP, amylin, and calcitonin receptors with enhanced metabolic benefits in animal models of obesity
The Triple Agonist Mechanism and Weight Loss Huberman described retatrutide as a triple agonist of the GLP-1, glucagon, and GIP receptors, and noted that it is sometimes referred to as "GLP-3." He made a striking claim about the weight loss data: "In a phase three clinical trial in humans, it caused up to one-third loss of body weight
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